Usually , clr is binding to c1inh ( cl inhibitor ) . when immune complex ( ic ) binds to clq , c1inh is detached form clr , and then the serine protease is activated , and then the complement classical pathway is activated 在一般情況下, c1r與c1inh ( c1inhibitor )結(jié)合著,而一旦有免疫復合物( ic )結(jié)合到c1q上時,浙江大學碩士學位論文cllnh的抑制作用即行移除, clr的構(gòu)象發(fā)生改變,具有酶活性,從而啟動補體激活經(jīng)典途徑。
The presence of complement - like activity in the humoral fluid of amphioxus was examined . the complement classical pathway ( cp ) activity is assayed by determining the amount of serum required to hemolyse a given number of sensitized sheep red blood cells ( srbc ) , whereas the complement alternative pathway ( ap ) activity measured in the same manner , but by using rabbit red blood cells ( rarbc ) instead of sensitized srbc 文昌魚體液可溶解懸浮在10mmol legta - mg - gvb緩沖液中的正常的兔血紅細胞、綿羊紅細胞、及部分哺乳動物、鳥類、兩棲類和魚類的代表動物的血紅細胞;而在gvb ~ ( 2 + )緩沖液中時對抗體包被的綿羊紅細胞卻沒有溶血活性。